Welcome!

@DevOpsSummit Authors: Elizabeth White, Yeshim Deniz, Pat Romanski, Liz McMillan, Flint Brenton

News Feed Item

DNAPrint Pharmaceuticals / Harvard Medical School Study Shows Why PT-401 Is 'Significantly' More Effective Than Epoetin

DNAPrint Pharmaceuticals / Harvard Medical School Study Shows Why PT-401 Is 'Significantly' More Effective Than Epoetin

SARASOTA, FL -- (MARKET WIRE) -- 06/26/07 -- DNAPrint Genomics, Inc. (OTCBB: DNAG) today announced the results of a new study conducted to understand the binding of PT-401 and Epoetin to the EPO receptor in an attempt to explain why the Company's proprietary PT-401 protein is 'significantly' more effective than another prevalent drug, epoetin, in raising red blood cell counts.

The study revealed that less PT-401 is bound to the receptor and less is inactivated (inactivation is mostly done by a receptor-mediated clearance mechanism) resulting in a prolonged half-life. This binding feature of PT-401 explains the superior in vivo activity, implying important beneficial effects in patients. The study was presented by Dr. Sytkowski as part of the Annual Meeting of the European Renal Association in Barcelona, Spain, on June 23, 2007.

The experiments were conducted by the Company and Dr. Arthur Sytkowski, the Director of the Laboratory for Cell and Molecular Biology at Beth Israel Deaconess Medical Center (BIDMC) in Boston, an affiliate of the Harvard Medical School.

"Dr. Sytkowski is one of the foremost scientists in the field of therapeutic protein research, particularly Erythropoietin," stated DNAPrint Chairman and Chief Medical Officer Hector J. Gomez, M.D., Ph.D. "This study brings us one step closer to the day that PT-401, which in our studies appears to be superior to epoetin, may be available to benefit dialysis patients who suffer from anemia. DNAPrint® Pharmaceuticals looks forward to continuing our collaboration with Dr. Sytkowski on this important project."

PT-401 is a "Super EPO," a more powerful erythropoiesis stimulating agent than Erythropoietin, a well-known drug used for the treatment of anemia. Previously, DNAPrint Pharmaceuticals, the Company's wholly owned subsidiary announced three successful milestones related to PT-401: the use of CHO cell lines, the use of SDS-PAGE, a well-established separation technique for the testing of cell lines, and a specially developed isoelectric focusing (IEF) method. The initial research has been conducted in conjunction with Dr. Sytkowski.

About Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center is a patient care, teaching and research affiliate of Harvard Medical School, and ranks third in National Institutes of Health funding among independent hospitals nationwide. BIDMC is clinically affiliated with the Joslin Diabetes Center and is a research partner of Dana-Farber/Harvard Cancer Center. BIDMC is the official hospital of the Boston Red Sox. For more information, visit www.bidmc.harvard.edu.

About DNAPrint Genomics, Inc.

DNAPrint Genomics, Inc. (www.dnaprint.com) is a developer of genomics-based products and services in two primary markets: biomedical and forensics. DNAPrint Pharmaceuticals, Inc., a wholly owned subsidiary, develops diagnostic tests and theranostic products (drug/test combinations) using the Company's proprietary ancestry-informed genetic marker studies combined with proprietary computational modeling technology. Computational Biology and Pharmacogenomics services are also offered externally to biopharmaceutical companies. The Company's first theranostic product is PT-401, a "Super EPO" (erythropoietin) dimer protein drug for treatment of anemia in renal dialysis patients (with end stage renal disease). Preclinical and clinical development of all the Company's drug candidates will benefit from simulated pre-trials to design actual trials better and are targeted to patients with genetic profiles indicating their propensity to have the best clinical responses. DNAPrint is proud of its continued dedication to developing and supplying new technological advances in law enforcement and consumer ancestry heritage interests. Please refer to www.dnaprint.com for information on law enforcement and consumer applications which include DNAWITNESS(TM), RETINOME(TM), ANCESTRYbyDNA(TM) and EURO-DNA(TM). DNAWitness-Y and DNAWitness-Mito are two tests offered by the Company. The results from these tests may be used as identification tools when a DNA sample is deteriorated or compromised or other DNA testing fails to yield acceptable results.

Forward-Looking Statements

All statements in this press release that are not historical are forward-looking statements. Such statements are subject to risks and uncertainties that could cause actual results to differ materially from those projected, including, but not limited to, uncertainties relating to technologies, product development, manufacturing, market acceptance, cost and pricing of DNAPrint's products, dependence on collaborations and partners, regulatory approvals, competition, intellectual property of others, and patent protection and litigation. DNAPrint Genomics, Inc. expressly disclaims any obligation or undertaking, except as may be required by applicable law or regulation to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in DNAPrint's expectations with regard thereto or any change in events, conditions, or circumstances on which any such statements are based.

Company Contact:
Richard Gabriel
CEO and President
941-366-3400
-or-
Ron Stabiner
The Wall Street Group, Inc.
212-888-4848

More Stories By Marketwired .

Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.

@DevOpsSummit Stories
DXWorldEXPO LLC, the producer of the world's most influential technology conferences and trade shows has announced the 22nd International CloudEXPO | DXWorldEXPO "Early Bird Registration" is now open. Register for Full Conference "Gold Pass" ▸ Here (Expo Hall ▸ Here)
More and more brands have jumped on the IoT bandwagon. We have an excess of wearables – activity trackers, smartwatches, smart glasses and sneakers, and more that track seemingly endless datapoints. However, most consumers have no idea what “IoT” means. Creating more wearables that track data shouldn't be the aim of brands; delivering meaningful, tangible relevance to their users should be. We're in a period in which the IoT pendulum is still swinging. Initially, it swung toward "smart for smart's sake," and many brands remain in that corner. But many brands are also gradually opting for more strategic approaches. They're taking a breath and stepping back to examine both existing and potential IoT experiences, asking themselves whether their products lend real value. Once we reach this goal, the implications for personalization are staggering. Consumers will expect devices they use and i...
Here are the Top 20 Twitter Influencers of the month as determined by the Kcore algorithm, in a range of current topics of interest from #IoT to #DeepLearning. To run a real-time search of a given term in our website and see the current top influencers, click on the topic name. Among the top 20 IoT influencers, ThingsEXPO ranked #14 and CloudEXPO ranked #17.
Without lifecycle traceability and visibility across the tool chain, stakeholders from Planning-to-Ops have limited insight and answers to who, what, when, why and how across the DevOps lifecycle. This impacts the ability to deliver high quality software at the needed velocity to drive positive business outcomes. In his general session at @DevOpsSummit at 19th Cloud Expo, Eric Robertson, General Manager at CollabNet, will discuss how customers are able to achieve a level of transparency that enables everyone from Planning-to-Ops to make informed decisions based on business priority and leverage automation to accelerate identifying issues and fast fix to drive continuous feedback and KPI insight.
Join IBM November 1 at 21st Cloud Expo at the Santa Clara Convention Center in Santa Clara, CA, and learn how IBM Watson can bring cognitive services and AI to intelligent, unmanned systems. Cognitive analysis impacts today’s systems with unparalleled ability that were previously available only to manned, back-end operations. Thanks to cloud processing, IBM Watson can bring cognitive services and AI to intelligent, unmanned systems. Imagine a robot vacuum that becomes your personal assistant that knows everything and can respond to your emotions and verbal commands!